Semaglutide

CAS Number: 910463-68-2
Molecular Formula: C₁₈₇H₂₉₁N₄₅O₅₉
Molecular Weight: 4113.58 g/mol
Sequence: HAEGTFTSDVSSYLEGQAAKEFIAWLVKGRG–E (with modifications for stability and activity)

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Semaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist, originally developed through structural modifications of the native GLP-1 molecule. These modifications include the substitution of amino acid residues and the addition of a C-18 fatty diacid chain via a spacer at position 26, which significantly enhances plasma stability and extends half-life, making it suitable for once-weekly administration in clinical settings.

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Research Applications

Semaglutide is widely studied in metabolic and endocrinological research, with a primary focus on:

Glycemic Control: Investigating its effects on insulin secretion, glucagon suppression, and delayed gastric emptying.

Appetite Regulation: Evaluating central nervous system impacts on satiety and food intake.

Weight Management: Exploring its role in body composition modulation in metabolic disease models.

Cardiometabolic Health: Studying potential cardiovascular benefits and inflammatory biomarker response.

This compound has demonstrated high binding affinity to GLP-1 receptors and has been extensively evaluated in both in vivo and in vitro models.

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For Research Use Only

Semaglutide offered by PeptideStock.com is strictly intended for qualified research professionals and institutions. This product is not for human consumption, medical, or veterinary use. Proper handling protocols and storage procedures are required.