SS-31: 5 Vial Bundle

SS-31 is a mitochondria-targeted tetrapeptide studied for its unique ability to selectively bind to cardiolipin within the inner mitochondrial membrane. This interaction has made SS-31 a compound of interest in research involving mitochondrial bioenergetics, oxidative stress, and cellular resilience.

Unlike traditional antioxidants, SS-31 acts at the mitochondrial membrane level, supporting structural integrity and functional efficiency of the electron transport chain in research models.

Research Overview

• Mitochondria-targeted tetrapeptide
• Selectively associates with cardiolipin
• Studied for mitochondrial membrane stabilization
• Explored in oxidative stress and energy metabolism research
• Frequently investigated in age-related and metabolic pathways

Mechanism of Action 

• SS-31 penetrates cell membranes and localizes within mitochondria, where it binds to cardiolipin, a phospholipid essential for maintaining mitochondrial cristae structure and electron transport chain function.
• In laboratory and clinical research settings, this interaction has been associated with:
• Improved mitochondrial membrane stability
• Reduced excessive reactive oxygen species (ROS) production
• Enhanced electron transport efficiency
• Preservation of ATP production under stress conditions
• Because of this targeted mechanism, SS-31 is often studied as a mitochondrial modulator rather than a conventional antioxidant.

Potential Research Applications

• Mitochondrial dysfunction and bioenergetics studies
• Oxidative stress and cellular aging models
• Cardiac and skeletal muscle research
• Neurodegenerative pathway investigations
• Cellular resilience under ischemic or inflammatory conditions
• SS-31 is intended for use in controlled laboratory research environments by qualified professionals.

Specifications

• Sequence: D-Arg-Dmt-Lys-Phe-NH₂
• Form: Lyophilized powder
• Purity: ≥99% (HPLC)
• Appearance: White to off-white powder
• Testing: HPLC and Mass Spectrometry
• Storage: Store lyophilized at −20°C; protect from light and moisture